Synthesis of gem-difluoromethylenated analogues of boronolide

• Jing Lin,
• Xiao-Long Qiu and
• Feng-Ling Qing

Beilstein J. Org. Chem. 2010, 6, No. 37, doi:10.3762/bjoc.6.37

• aldehyde 9 with the fluorine-containing building block 11 and the efficient construction of α,β-unsaturated-δ-lactones 15a–b via BAIB/TEMPO-procedure. Keywords: boronolide; gem-difluoromethylenated analogues; gem-difluoropropargylation; α,β-unsaturated-δ-lactones; Introduction (+)-Boronolide (1

• and the efficient construction of α,β-unsaturated-δ-lactones 15a–b via the BAIB/TEMPO-procedure. Boronolide (1), boronolide analogues 2–3 and gem-difluoromethylenated analogues 4–7. Retrosynthetic analysis of target molecules 4–7. Synthesis of target molecules 4–5. Synthesis of target molecules 6–7