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Thematic Series, edited by Prof. Joseph P. Michael, University of the Witwatersrand

Alkaloids are assembled from a relatively small number of structural motifs. Among the motifs that are most frequently encountered are bicyclic systems containing bridgehead nitrogen – the indolizidines and quinolizidines. These two azabicyclic systems may occur in the natural products either in isolation or, more commonly, embedded within fused polycyclic arrays. It was estimated that between 25% and 30% of all alkaloids possess structures incorporating one or other of these motifs. Structural, spectroscopic and computational studies on both natural and synthetic indolizidines and quinolizidines are reported regularly.

In this Thematic Series, there are representative articles covering several of these aspects. A number of authors have contributed reviews in which their own contributions to the development of indolizidine and quinolizidine chemistry are highlighted. There are articles on the total synthesis of relevant natural products, as well as articles describing novel methodological approaches to the systems of interest.

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