Chemistry in flow systems

  1. editorImage
  1. Editor: Prof. Andreas Kirschning
    Leibniz Universität Hannover

The automation of chemical synthesis with the resulting savings in time and materials and reduction in the use of environmentally harmful chemicals has been the goal of many academic and industrial chemists for a long time. Over recent years the application of flow devices in laboratories has been gaining acceptance with increased sophistication in their control and ease of use. The advantages that flow devices bring are many, for example: easier scale up, better and precise control of reaction conditions, better mixing, easier handling of unstable intermediates, in-system purification. An important field of research is the optimization and adaptation of known reactions and reaction sequences for use in flow systems. Continuous-flow processes can be further improved by techniques that use immobilized reagents or catalysts, or by using fixed bed reactors in parallel. These developments in flow techniques using mini and micro flow reactors have initiated changes that will pave the way for a technological step forward in chemical synthesis.

See also the Thematic Series:
Chemistry in flow systems III
Chemistry in flow systems II

See videos about flow chemistry at Beilstein TV.

Chemistry in flow systems

  1. Andreas Kirschning
  • Editorial
  • Published 29 Apr 2009

Beilstein J. Org. Chem. 2009, 5, No. 15, doi:10.3762/bjoc.5.15

  • Full Research Paper
  • Published 29 Apr 2009

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  • Supp. Info

Beilstein J. Org. Chem. 2009, 5, No. 16, doi:10.3762/bjoc.5.16

  • Full Research Paper
  • Published 29 Apr 2009

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  • Supp. Info

Beilstein J. Org. Chem. 2009, 5, No. 17, doi:10.3762/bjoc.5.17

Oxidative cyclization of alkenols with Oxone using a miniflow reactor

  1. Yoichi M. A. Yamada,
  2. Kaoru Torii and
  3. Yasuhiro Uozumi
  • Preliminary Communication
  • Published 29 Apr 2009

Beilstein J. Org. Chem. 2009, 5, No. 18, doi:10.3762/bjoc.5.18

Asymmetric reactions in continuous flow

  1. Xiao Yin Mak,
  2. Paola Laurino and
  3. Peter H. Seeberger
  • Review
  • Published 29 Apr 2009

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Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

  • Full Research Paper
  • Published 08 May 2009

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Beilstein J. Org. Chem. 2009, 5, No. 21, doi:10.3762/bjoc.5.21

Continuous flow based catch and release protocol for the synthesis of α-ketoesters

  1. Alessandro Palmieri,
  2. Steven V. Ley,
  3. Anastasios Polyzos,
  4. Mark Ladlow and
  5. Ian R. Baxendale
  • Full Research Paper
  • Published 20 May 2009

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Beilstein J. Org. Chem. 2009, 5, No. 23, doi:10.3762/bjoc.5.23

  • Full Research Paper
  • Published 02 Jun 2009

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Beilstein J. Org. Chem. 2009, 5, No. 27, doi:10.3762/bjoc.5.27

  • Full Research Paper
  • Published 09 Jun 2009

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Beilstein J. Org. Chem. 2009, 5, No. 29, doi:10.3762/bjoc.5.29

  • Full Research Paper
  • Published 12 Jun 2009

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Beilstein J. Org. Chem. 2009, 5, No. 30, doi:10.3762/bjoc.5.30

Radical carbonylations using a continuous microflow system

  1. Takahide Fukuyama,
  2. Md. Taifur Rahman,
  3. Naoya Kamata and
  4. Ilhyong Ryu
  • Preliminary Communication
  • Published 13 Jul 2009

  • PDF

Beilstein J. Org. Chem. 2009, 5, No. 34, doi:10.3762/bjoc.5.34

  • Full Research Paper
  • Published 21 Jul 2009

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  • Supp. Info

Beilstein J. Org. Chem. 2009, 5, No. 35, doi:10.3762/bjoc.5.35

  • Review
  • Published 20 Aug 2009

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Beilstein J. Org. Chem. 2009, 5, No. 40, doi:10.3762/bjoc.5.40

Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups

  1. Julien Rolland,
  2. Xacobe C. Cambeiro,
  3. Carles Rodríguez-Escrich and
  4. Miquel A. Pericàs
  • Full Research Paper
  • Published 15 Oct 2009

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Beilstein J. Org. Chem. 2009, 5, No. 56, doi:10.3762/bjoc.5.56

  • Full Research Paper
  • Published 30 Nov 2009

Beilstein J. Org. Chem. 2009, 5, No. 70, doi:10.3762/bjoc.5.70

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