Chemistry in flow systems

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Editor: Prof. Andreas Kirschning
Leibniz Universität Hannover
 
The automation of chemical synthesis with the resulting savings in time and materials and reduction in the use of environmentally harmful chemicals has been the goal of many academic and industrial chemists for a long time. Over recent years the application of flow devices in laboratories has been gaining acceptance with increased sophistication in their control and ease of use. The advantages that flow devices bring are many, for example: easier scale up, better and precise control of reaction conditions, better mixing, easier handling of unstable intermediates, in-system purification. An important field of research is the optimization and adaptation of known reactions and reaction sequences for use in flow systems. Continuous-flow processes can be further improved by techniques that use immobilized reagents or catalysts, or by using fixed bed reactors in parallel. These developments in flow techniques using mini and micro flow reactors have initiated changes that will pave the way for a technological step forward in chemical synthesis.

See also the Thematic Series:
Chemistry in flow systems III
Chemistry in flow systems II

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Chemistry in flow systems

  • Andreas Kirschning

Beilstein J. Org. Chem. 2009, 5, No. 15, doi:10.3762/bjoc.5.15

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Published 29 Apr 2009

Synthesis of unsymmetrically substituted biaryls via sequential lithiation of dibromobiaryls using integrated microflow systems

  • Aiichiro Nagaki,
  • Naofumi Takabayashi,
  • Yutaka Tomida and
  • Jun-ichi Yoshida

Beilstein J. Org. Chem. 2009, 5, No. 16, doi:10.3762/bjoc.5.16

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Published 29 Apr 2009

A biphasic oxidation of alcohols to aldehydes and ketones using a simplified packed- bed microreactor

  • Andrew Bogdan and
  • D. Tyler McQuade

Beilstein J. Org. Chem. 2009, 5, No. 17, doi:10.3762/bjoc.5.17

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Published 29 Apr 2009

Oxidative cyclization of alkenols with Oxone using a miniflow reactor

  • Yoichi M. A. Yamada,
  • Kaoru Torii and
  • Yasuhiro Uozumi

Beilstein J. Org. Chem. 2009, 5, No. 18, doi:10.3762/bjoc.5.18

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Preliminary Communication
Published 29 Apr 2009

Asymmetric reactions in continuous flow

  • Xiao Yin Mak,
  • Paola Laurino and
  • Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

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Published 29 Apr 2009

Polyionic polymers – heterogeneous media for metal nanoparticles as catalyst in Suzuki–Miyaura and Heck–Mizoroki reactions under flow conditions

  • Klaas Mennecke and
  • Andreas Kirschning

Beilstein J. Org. Chem. 2009, 5, No. 21, doi:10.3762/bjoc.5.21

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Published 08 May 2009

Continuous flow based catch and release protocol for the synthesis of α-ketoesters

  • Alessandro Palmieri,
  • Steven V. Ley,
  • Anastasios Polyzos,
  • Mark Ladlow and
  • Ian R. Baxendale

Beilstein J. Org. Chem. 2009, 5, No. 23, doi:10.3762/bjoc.5.23

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Published 20 May 2009

The development and evaluation of a continuous flow process for the lipase- mediated oxidation of alkenes

  • Charlotte Wiles,
  • Marcus J. Hammond and
  • Paul Watts

Beilstein J. Org. Chem. 2009, 5, No. 27, doi:10.3762/bjoc.5.27

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Published 02 Jun 2009

From discovery to production: Scale- out of continuous flow meso reactors

  • Peter Styring and
  • Ana I. R. Parracho

Beilstein J. Org. Chem. 2009, 5, No. 29, doi:10.3762/bjoc.5.29

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Published 09 Jun 2009

Controlling hazardous chemicals in microreactors: Synthesis with iodine azide

  • Johan C. Brandt and
  • Thomas Wirth

Beilstein J. Org. Chem. 2009, 5, No. 30, doi:10.3762/bjoc.5.30

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Published 12 Jun 2009

Radical carbonylations using a continuous microflow system

  • Takahide Fukuyama,
  • Md. Taifur Rahman,
  • Naoya Kamata and
  • Ilhyong Ryu

Beilstein J. Org. Chem. 2009, 5, No. 34, doi:10.3762/bjoc.5.34

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Preliminary Communication
Published 13 Jul 2009

Gold film- catalysed benzannulation by Microwave- Assisted, Continuous Flow Organic Synthesis (MACOS)

  • Gjergji Shore,
  • Michael Tsimerman and
  • Michael G. Organ

Beilstein J. Org. Chem. 2009, 5, No. 35, doi:10.3762/bjoc.5.35

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Published 21 Jul 2009

Acid- mediated reactions under microfluidic conditions: A new strategy for practical synthesis of biofunctional natural products

  • Katsunori Tanaka and
  • Koichi Fukase

Beilstein J. Org. Chem. 2009, 5, No. 40, doi:10.3762/bjoc.5.40

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Published 20 Aug 2009

Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups

  • Julien Rolland,
  • Xacobe C. Cambeiro,
  • Carles Rodríguez-Escrich and
  • Miquel A. Pericàs

Beilstein J. Org. Chem. 2009, 5, No. 56, doi:10.3762/bjoc.5.56

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Published 15 Oct 2009
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Published 30 Nov 2009
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