Nucleic acid chemistry

  1. editorImage
  1. Editor: Prof. Hans-Achim Wagenknecht
    Karlsruhe Institute of Technology

Since the discovery of the structure of the DNA double helix in 1953, we know that DNA is of critical importance, carrying the genetic information for all living organisms. Only a few years later the first reports on the chemical synthesis of oligonucleotides appeared. During the past years the field of nucleic acid chemistry has expanded dramatically: natural and artificial functionalities, as well as probes, markers or other biologically active molecules, can be synthetically introduced into DNA (as well as RNA) by preparing the corresponding artificial DNA and RNA building blocks. Although nucleic acid chemistry appears to be a mature part of organic and bioorganic chemistry, the many questions that are still being raised give sufficient motivation to continue to synthesize new nucleic acid probes. Moreover, in addition to their biological functionality, DNA and RNA are considered as increasingly important architectures and scaffolds for two- and three-dimensional objects, networks and materials for nanosciences.

Nucleic acid chemistry

  1. Hans-Achim Wagenknecht
  • Editorial
  • Published 10 Dec 2014

Beilstein J. Org. Chem. 2014, 10, 2928–2929, doi:10.3762/bjoc.10.311

A new building block for DNA network formation by self-assembly and polymerase chain reaction

  1. Holger Bußkamp,
  2. Sascha Keller,
  3. Marta Robotta,
  4. Malte Drescher and
  5. Andreas Marx
  • Full Research Paper
  • Published 07 May 2014

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Beilstein J. Org. Chem. 2014, 10, 1037–1046, doi:10.3762/bjoc.10.104

Pyrene-modified PNAs: Stacking interactions and selective excimer emission in PNA2DNA triplexes

  1. Alex Manicardi,
  2. Lucia Guidi,
  3. Alice Ghidini and
  4. Roberto Corradini
  • Full Research Paper
  • Published 02 Jul 2014

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Beilstein J. Org. Chem. 2014, 10, 1495–1503, doi:10.3762/bjoc.10.154

  • Full Research Paper
  • Published 11 Jul 2014

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Beilstein J. Org. Chem. 2014, 10, 1589–1595, doi:10.3762/bjoc.10.164

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  • Published 12 Aug 2014

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Beilstein J. Org. Chem. 2014, 10, 1840–1847, doi:10.3762/bjoc.10.194

  • Full Research Paper
  • Published 15 Aug 2014

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Beilstein J. Org. Chem. 2014, 10, 1906–1913, doi:10.3762/bjoc.10.198

  • Full Research Paper
  • Published 18 Aug 2014

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Beilstein J. Org. Chem. 2014, 10, 1914–1918, doi:10.3762/bjoc.10.199

Pyrrolidine nucleotide analogs with a tunable conformation

  1. Lenka Poštová Slavětínská,
  2. Dominik Rejman and
  3. Radek Pohl
  • Full Research Paper
  • Published 22 Aug 2014

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Beilstein J. Org. Chem. 2014, 10, 1967–1980, doi:10.3762/bjoc.10.205

Synthesis of phosphoramidites of isoGNA, an isomer of glycerol nucleic acid

  1. Keunsoo Kim,
  2. Venkateshwarlu Punna,
  3. Phaneendrasai Karri and
  4. Ramanarayanan Krishnamurthy
  • Full Research Paper
  • Published 08 Sep 2014

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Beilstein J. Org. Chem. 2014, 10, 2131–2138, doi:10.3762/bjoc.10.220

Second generation silver(I)-mediated imidazole base pairs

  1. Susanne Hensel,
  2. Nicole Megger,
  3. Kristina Schweizer and
  4. Jens Müller
  • Full Research Paper
  • Published 09 Sep 2014

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Beilstein J. Org. Chem. 2014, 10, 2139–2144, doi:10.3762/bjoc.10.221

Synthesis and optical properties of pyrrolidinyl peptide nucleic acid carrying a clicked Nile red label

  1. Nattawut Yotapan,
  2. Chayan Charoenpakdee,
  3. Pawinee Wathanathavorn,
  4. Boonsong Ditmangklo,
  5. Hans-Achim Wagenknecht and
  6. Tirayut Vilaivan
  • Full Research Paper
  • Published 11 Sep 2014

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Beilstein J. Org. Chem. 2014, 10, 2166–2174, doi:10.3762/bjoc.10.224

Molecular recognition of AT-DNA sequences by the induced CD pattern of dibenzotetraaza[14]annulene (DBTAA)–adenine derivatives

  1. Marijana Radić Stojković,
  2. Marko Škugor,
  3. Łukasz Dudek,
  4. Jarosław Grolik,
  5. Julita Eilmes and
  6. Ivo Piantanida
  • Full Research Paper
  • Published 12 Sep 2014

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Beilstein J. Org. Chem. 2014, 10, 2175–2185, doi:10.3762/bjoc.10.225

Solution phase synthesis of short oligoribonucleotides on a precipitative tetrapodal support

  1. Alejandro Gimenez Molina,
  2. Amit M. Jabgunde,
  3. Pasi Virta and
  4. Harri Lönnberg
  • Full Research Paper
  • Published 29 Sep 2014

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Beilstein J. Org. Chem. 2014, 10, 2279–2285, doi:10.3762/bjoc.10.237

  • Full Research Paper
  • Published 01 Oct 2014

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Beilstein J. Org. Chem. 2014, 10, 2293–2306, doi:10.3762/bjoc.10.239

  • Full Research Paper
  • Published 02 Oct 2014

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Beilstein J. Org. Chem. 2014, 10, 2307–2321, doi:10.3762/bjoc.10.240

  • Full Research Paper
  • Published 04 Nov 2014

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Beilstein J. Org. Chem. 2014, 10, 2566–2572, doi:10.3762/bjoc.10.268

Come-back of phenanthridine and phenanthridinium derivatives in the 21st century

  1. Lidija-Marija Tumir,
  2. Marijana Radić Stojković and
  3. Ivo Piantanida
  • Review
  • Published 10 Dec 2014

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Beilstein J. Org. Chem. 2014, 10, 2930–2954, doi:10.3762/bjoc.10.312

  • Full Research Paper
  • Published 11 Dec 2014

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Beilstein J. Org. Chem. 2014, 10, 2963–2974, doi:10.3762/bjoc.10.314

  • Full Research Paper
  • Published 13 Jan 2015

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Beilstein J. Org. Chem. 2015, 11, 50–60, doi:10.3762/bjoc.11.8

  • Full Research Paper
  • Published 30 Jan 2015

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Beilstein J. Org. Chem. 2015, 11, 184–191, doi:10.3762/bjoc.11.19

  • Full Research Paper
  • Published 09 Feb 2015

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Beilstein J. Org. Chem. 2015, 11, 219–227, doi:10.3762/bjoc.11.24

C-5’-Triazolyl-2’-oxa-3’-aza-4’a-carbanucleosides: Synthesis and biological evaluation

  1. Roberto Romeo,
  2. Caterina Carnovale,
  3. Salvatore V. Giofrè,
  4. Maria A. Chiacchio,
  5. Adriana Garozzo,
  6. Emanuele Amata,
  7. Giovanni Romeo and
  8. Ugo Chiacchio
  • Full Research Paper
  • Published 09 Mar 2015

Beilstein J. Org. Chem. 2015, 11, 328–334, doi:10.3762/bjoc.11.38

A procedure for the preparation and isolation of nucleoside-5’-diphosphates

  1. Heidi J. Korhonen,
  2. Hannah L. Bolt and
  3. David R. W. Hodgson
  • Letter
  • Published 10 Apr 2015

Beilstein J. Org. Chem. 2015, 11, 469–472, doi:10.3762/bjoc.11.52

Sequence-specific RNA cleavage by PNA conjugates of the metal-free artificial ribonuclease tris(2-aminobenzimidazole)

  1. Friederike Danneberg,
  2. Alice Ghidini,
  3. Plamena Dogandzhiyski,
  4. Elisabeth Kalden,
  5. Roger Strömberg and
  6. Michael W. Göbel
  • Full Research Paper
  • Published 16 Apr 2015

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Beilstein J. Org. Chem. 2015, 11, 493–498, doi:10.3762/bjoc.11.55

  • Full Research Paper
  • Published 01 Jun 2015

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Beilstein J. Org. Chem. 2015, 11, 913–929, doi:10.3762/bjoc.11.103

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