C–H Functionalization/activation in organic synthesis

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Editor: Prof. Richmond Sarpong
University of California, Berkeley
 
The last decade has seen an explosion in research reports in the area of C–H functionalization and activation in organic synthesis. Since organic compounds mainly consist of a carbon skeleton that bears a large number of hydrogens, it is highly desirable to be able to take advantage of the myriad of C–H groups in organic molecules as functional handles for bond formation, and in some cases, bond-breaking processes. In this Thematic Series, a collection of ten contributions from researchers in the area of C–H functionalization from Europe, United States, Japan, China, India, and Brazil is presented. These contributions include full accounts on primary research in the area of C–H functionalization and activation and reviews that focus on aspects of this exciting field.

See also the Thematic Series:
C–H Functionalization

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C–H Functionalization/activation in organic synthesis

  • Richmond Sarpong

Beilstein J. Org. Chem. 2016, 12, 2315–2316, doi:10.3762/bjoc.12.224

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Published 03 Nov 2016

Pyridylidene ligand facilitates gold-catalyzed oxidative C–H arylation of heterocycles

  • Kazuhiro Hata,
  • Hideto Ito,
  • Yasutomo Segawa and
  • Kenichiro Itami

Beilstein J. Org. Chem. 2015, 11, 2737–2746, doi:10.3762/bjoc.11.295

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Full Research Paper
Published 28 Dec 2015

Iridium/N-heterocyclic carbene-catalyzed C–H borylation of arenes by diisopropylaminoborane

  • Mamoru Tobisu,
  • Takuya Igarashi and
  • Naoto Chatani

Beilstein J. Org. Chem. 2016, 12, 654–661, doi:10.3762/bjoc.12.65

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Published 07 Apr 2016

Opportunities and challenges for direct C–H functionalization of piperazines

  • Zhishi Ye,
  • Kristen E. Gettys and
  • Mingji Dai

Beilstein J. Org. Chem. 2016, 12, 702–715, doi:10.3762/bjoc.12.70

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Review
Published 13 Apr 2016

Gold-catalyzed direct alkynylation of tryptophan in peptides using TIPS-EBX

  • Gergely L. Tolnai,
  • Jonathan P. Brand and
  • Jerome Waser

Beilstein J. Org. Chem. 2016, 12, 745–749, doi:10.3762/bjoc.12.74

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Letter
Published 19 Apr 2016

Recent advances in C(sp3)–H bond functionalization via metal–carbene insertions

  • Bo Wang,
  • Di Qiu,
  • Yan Zhang and
  • Jianbo Wang

Beilstein J. Org. Chem. 2016, 12, 796–804, doi:10.3762/bjoc.12.78

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Review
Published 25 Apr 2016

Enantioselective carbenoid insertion into C(sp3)–H bonds

  • J. V. Santiago and
  • A. H. L. Machado

Beilstein J. Org. Chem. 2016, 12, 882–902, doi:10.3762/bjoc.12.87

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Review
Published 04 May 2016

The synthesis of functionalized bridged polycycles via C–H bond insertion

  • Jiun-Le Shih,
  • Po-An Chen and
  • Jeremy A. May

Beilstein J. Org. Chem. 2016, 12, 985–999, doi:10.3762/bjoc.12.97

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Review
Published 17 May 2016

Cationic Pd(II)-catalyzed C–H activation/cross-coupling reactions at room temperature: synthetic and mechanistic studies

  • Takashi Nishikata,
  • Alexander R. Abela,
  • Shenlin Huang and
  • Bruce H. Lipshutz

Beilstein J. Org. Chem. 2016, 12, 1040–1064, doi:10.3762/bjoc.12.99

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Published 20 May 2016

Synthesis of 2-oxindoles via 'transition-metal-free' intramolecular dehydrogenative coupling (IDC) of sp2 C–H and sp3 C–H bonds

  • Nivesh Kumar,
  • Santanu Ghosh,
  • Subhajit Bhunia and
  • Alakesh Bisai

Beilstein J. Org. Chem. 2016, 12, 1153–1169, doi:10.3762/bjoc.12.111

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Published 08 Jun 2016

Palladium-catalyzed picolinamide-directed iodination of remote ortho-C−H bonds of arenes: Synthesis of tetrahydroquinolines

  • William A. Nack,
  • Xinmou Wang,
  • Bo Wang,
  • Gang He and
  • Gong Chen

Beilstein J. Org. Chem. 2016, 12, 1243–1249, doi:10.3762/bjoc.12.119

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Published 17 Jun 2016

Direct arylation catalysis with chloro[8-(dimesitylboryl)quinoline-κN]copper(I)

  • Sem Raj Tamang and
  • James D. Hoefelmeyer

Beilstein J. Org. Chem. 2016, 12, 2757–2762, doi:10.3762/bjoc.12.272

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Published 15 Dec 2016
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