An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals

Scholarly Works

• Sunny, S.; Maingle, M.; Sheeba, L.; Pathan, F. R.; J., G. S.; Juloori, H.; Gadewar, S. G.; Seth, K. Cu(ii)-catalyzed 'in-water' N-arylation of electron-deficient NH-heterocycles. Green Chemistry 2024, 26, 3149–3158. doi:10.1039/d3gc05163c
• Bombonato, E.; Fasano, V.; Pecorari, D.; Fornasari, L.; Castagnini, F.; Marcaccio, M.; Ronchi, P. Electrochemical Synthesis of Unnatural Amino Acids Embedding 5- and 6-Membered Heteroaromatics. ACS omega 2024, 9, 13081. doi:10.1021/acsomega.3c09357
• Fan, J.; Zu, Y.; Zheng, Z.; Song, L.; Wang, Y.; Zhou, Z.; Liu, Y.; Xu, S. A silver-mediated radical process of β-keto sulfones for the synthesis of 2,3-diacyl furans. Organic & biomolecular chemistry 2024, 22, 1770–1774. doi:10.1039/d3ob02079g
• Tsurugi, H.; Akiyama, T.; Frye, C. W.; Kakiuchi, Y.; Mashima, K.; Tonks, I. A. Evaluation of Tungsten Catalysis among Early Transition Metals for N-Aryl-2,3,4,5-tetraarylpyrrole Synthesis: Modular Access to N-Doped π-Conjugated Material Precursors. Inorganic chemistry 2024, 63, 3037–3046. doi:10.1021/acs.inorgchem.3c03858
• Gao, P.; Wang, Z.; Chang, R.; Li, W.; Zhao, Z.; Fu, D.; Liu, Q. Ruthenium/HI-catalyzed direct hydromethylation of indoles and quinolines in DME. New Journal of Chemistry 2024, 48, 1227–1232. doi:10.1039/d3nj03341d
• Natarajan, P.; Kanchithalaivan, S.; Chatterjee, A.; Peruncheralathan, S. Organocatalytic Chemoselective C4‐Benzylation of 5‐Aminopyrazoles. Asian Journal of Organic Chemistry 2024. doi:10.1002/ajoc.202300628
• Rani, S.; Aslam, S.; Lal, K.; Noreen, S.; Alsader, K. A. M.; Hussain, R.; Shirinfar, B.; Ahmed, N. Electrochemical C-H/C-C Bond Oxygenation: A Potential Technology for Plastic Depolymerization. Chemical record (New York, N.Y.) 2023, 24, e202300331. doi:10.1002/tcr.202300331
• Sharma, A. N.; Verma, R. Source, Synthesis, and Biological Evaluation of Natural Occurring 2,2'-Bipyridines. Chemistry & biodiversity 2023, 20, e202300764. doi:10.1002/cbdv.202300764
• Benhassine, A.; Chouiter, M. I.; Kara-Ali, M.; Kacem-Chaouche, N.; Merazig, H.; Belfaitah, A. Synthesis, characterization, spectroscopic study and biological evaluation of Zn(II), Ni(II), and Cu(II)complexes derived from(1-methyl-1H-imidazol-2-yl)methanol. Journal of Molecular Structure 2023, 1294, 136261. doi:10.1016/j.molstruc.2023.136261
• Kim, Y.; Kim, Y.; Kim, S.-G. [4+2]-Cycloaddition of 2-Aminophenyl Enones with Cyclic N-Sulfimines to Access Enantioenriched Ring-Fused Aminals. Chemistry, an Asian journal 2023, 19, e202301011. doi:10.1002/asia.202301011
• Martelli, L. S. R.; da Silva, O. A. M.; Zukerman-Schpector, J.; Corrêa, A. G. One-pot synthesis of γ-lactams from ketoaziridines. Organic & biomolecular chemistry 2023, 21, 9128–9132. doi:10.1039/d3ob01568h
• Hammer, S.; Nanto, F.; Canu, P.; Ötvös, S. B.; Kappe, C. O. Application of an Oscillatory Plug Flow Reactor to Enable Scalable and Fast Reactions in Water Using a Biomass-Based Polymeric Additive. ChemSusChem 2023, 17, e202301149. doi:10.1002/cssc.202301149
• Kumar, M. B.; Hariprasad, V.; Joshi, S. D.; Naik, P.; Jayaprakash, G. K.; Pani, A. S.; Babu, D. D. Exploring the Antimicrobial Potential of Pyrimidine Linked Hydrazinyl Azole Derivatives: Insights from Biological Assays and Molecular Docking Studies. ChemistrySelect 2023, 8. doi:10.1002/slct.202301998
• Ou, C.; Ghosh, B.; Sharma, I. A non-diazo approach to functionalized (2-furyl)-2-pyrrolidines through a cascade reaction of enynal-derived zinc carbenoids with β-arylaminoketones. Organic Chemistry Frontiers 2023, 10, 5933–5939. doi:10.1039/d3qo01354e
• Li, X.; Chen, X.-Y.; Fan, B.-Y.; Yu, Q.; Lei, J.; Xu, Z.-G.; Chen, Z.-Z. Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity. Molecules (Basel, Switzerland) 2023, 28, 7602. doi:10.3390/molecules28227602
• Kornfeind, J.; Allen, J. E.; Keller, T. M.; Fleming, F. F. Heterocycles via SiCl4-Promoted Isocyanide Additions to Oxonitriles. The Journal of organic chemistry 2023, 88, 15947–15955. doi:10.1021/acs.joc.3c02210
• Cornella, J.; Spinnato, D.; Leutzsch, M.; Wang, F. Internal Atom Exchange in Oxazole Rings: A Blueprint for Azole Scaffold Evaluation. Synlett 2023. doi:10.1055/a-2201-9285
• Kommuri, V. C.; Vijayan, A.; Pawar, L.; Arunachalampillai, A. An Efficient Copper‐Catalyzed Regioselective One‐Pot Synthesis of Pyrido[1,2‐a]benzimidazole and Its Derivatives. ChemistrySelect 2023, 8. doi:10.1002/slct.202303000
• Whitehead, R. Z.; Norman, L. T.; Cull, W. J.; Fernandes, J. A.; Lanterna, A. E. Selective Excitation of Pd‐decorated Titania Enables Consecutive C−C Couplings and Hydrogenations under Ambient Conditions. ChemCatChem 2023, 15. doi:10.1002/cctc.202300528
• Haritha, M.; Suresh, C. H. The fundamental nature and importance of electrostatic potential in hydrogen bond formation: a case study of heterocycles frequently observed in drugs. New Journal of Chemistry 2023, 47, 17323–17332. doi:10.1039/d3nj02509h

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