Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction

Xiaoli Zhou, Meiling Liu, Puying Luo, Yingjun Lai, Tangtao Yang and Qiuping Ding
Beilstein J. Org. Chem. 2014, 10, 2286–2292. https://doi.org/10.3762/bjoc.10.238

Supporting Information

Supporting Information File 1: Characterization data and NMR spectra.
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Supporting Information File 2: X-ray data for compound 3b.
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Supporting Information File 3: X-ray data for compound 4h.
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Cite the Following Article

Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction
Xiaoli Zhou, Meiling Liu, Puying Luo, Yingjun Lai, Tangtao Yang and Qiuping Ding
Beilstein J. Org. Chem. 2014, 10, 2286–2292. https://doi.org/10.3762/bjoc.10.238

How to Cite

Zhou, X.; Liu, M.; Luo, P.; Lai, Y.; Yang, T.; Ding, Q. Beilstein J. Org. Chem. 2014, 10, 2286–2292. doi:10.3762/bjoc.10.238

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Scholarly Works

  • Singh, K. S.; Goankar, R. R.; Banerjee, K.; Kaminsky, W. Synthesis of pyrazolo[5,1-a]isoquinolines via C–H/N–H annulation of pyrazoles and alkynes with ruthenium(II) catalysts. Monatshefte für Chemie - Chemical Monthly 2023, 154, 905–914. doi:10.1007/s00706-023-03104-0
  • Wang, Z.; Li, X.; Qiu, J.; Li, W.; Li, H.; Weng, Z.; Li, H. Modular Access to 2-(Trifluoromethyl)pyrazolo[1,5-a]pyridines and Their Benzo Analogues through a Copper(I)-Catalyzed Radical Annulation. Organic letters 2022, 24, 6292–6297. doi:10.1021/acs.orglett.2c02500
  • Neetha, M.; Aneeja, T.; Afsina, C. M. A.; Anilkumar, G. An Overview of Ag-catalyzed Synthesis of Six-membered Heterocycles. ChemCatChem 2020, 12, 5330–5358. doi:10.1002/cctc.202000719
  • Wong, V. H. L.; Hii, K. Silver Catalysis in Organic Synthesis; Wiley, 2018; pp 85–181. doi:10.1002/9783527342822.ch3
  • Grošelj, U.; Svete, J.; Al Mamari, H. H.; Požgan, F.; Štefane, B. Metal-catalyzed [3+2] cycloadditions of azomethine imines. Chemistry of Heterocyclic Compounds 2018, 54, 214–240. doi:10.1007/s10593-018-2258-2
  • Dhiman, S.; Nandwana, N. K.; Saini, H. K.; Kumar, D.; Rangan, K.; Robertson, K. N.; Jha, M.; Kumar, A. Nickel‐Catalyzed Tandem Knoevenagel Condensation and Intramolecular Direct Arylation: Synthesis of Pyrazolo[5,1‐a]‐isoquinoline Derivatives. Advanced Synthesis & Catalysis 2018, 360, 1973–1983. doi:10.1002/adsc.201701519
  • Chen, W.; Ding, Q.; Nie, Z.; Peng, Y. Synthesis of 2-trifluoromethylquinolines via copper-mediated intramolecular oxidative cyclization of N-(2-alkenylaryl) enamines. RSC Advances 2016, 6, 48767–48773. doi:10.1039/c6ra09741c
  • Fang, G.; Bi, X. Silver-catalysed reactions of alkynes: recent advances. Chemical Society reviews 2015, 44, 8124–8173. doi:10.1039/c5cs00027k
  • Nájera, C.; Sansano, J. M.; Yus, M. 1,3-Dipolar cycloadditions of azomethine imines. Organic & biomolecular chemistry 2015, 13, 8596–8636. doi:10.1039/c5ob01086a

Patents

  • ZHAO YUNHUI; LI YUBO. Tetra-substituted pyrazol isoquinoline compound and synthetic method thereof. CN 105294689 A, Feb 3, 2016.
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