Chemical probes for competitive profiling of the quorum sensing signal synthase PqsD of Pseudomonas aeruginosa

Michaela Prothiwa, Dávid Szamosvári, Sandra Glasmacher and Thomas Böttcher
Beilstein J. Org. Chem. 2016, 12, 2784–2792. https://doi.org/10.3762/bjoc.12.277

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Chemical probes for competitive profiling of the quorum sensing signal synthase PqsD of Pseudomonas aeruginosa
Michaela Prothiwa, Dávid Szamosvári, Sandra Glasmacher and Thomas Böttcher
Beilstein J. Org. Chem. 2016, 12, 2784–2792. https://doi.org/10.3762/bjoc.12.277

How to Cite

Prothiwa, M.; Szamosvári, D.; Glasmacher, S.; Böttcher, T. Beilstein J. Org. Chem. 2016, 12, 2784–2792. doi:10.3762/bjoc.12.277

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  • Szamosvári, D.; Savchenko, V.; Badouin, N.; Böttcher, T. Beyond iron: metal-binding activity of the Pseudomonas quinolone signal-motif. Organic & biomolecular chemistry 2023, 21, 5158–5163. doi:10.1039/d3ob00710c
  • Empting, M. Quo vadis quorum sensing? Advances in disrupting the Pseudomonas quinolone signal (PQS). New Approaches Towards Novel Antibacterial Agents; Elsevier, 2023; pp 135–159. doi:10.1016/bs.armc.2023.09.004
  • Li; Peng, X.; Guo, Y.; Gong, S.; Cao, S.; Qiu, F. Currently Available Strategies for Target Identification of Bioactive Natural Products. Frontiers in chemistry 2021, 9, 761609. doi:10.3389/fchem.2021.761609
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  • Pawar, A.; Basler, M.; Goebel, H.; Salinas, G. O. A.; Groettrup, M.; Böttcher, T. Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome. ACS central science 2020, 6, 241–246. doi:10.1021/acscentsci.9b01170
  • Prothiwa, M.; Böttcher, T. Competitive profiling for enzyme inhibitors using chemical probes. Methods in enzymology 2019, 633, 49–69. doi:10.1016/bs.mie.2019.10.031
  • Modi, A.; Sau, P.; Chakraborty, N.; Patel, B. K. A “Thiocarbonyl‐Directed” Regiospecific C−H/S−H Annulation of Quinoline‐4(1 H )‐thiones with Alkynes. Advanced Synthesis & Catalysis 2019, 361, 1368–1375. doi:10.1002/adsc.201801537
  • Prothiwa, M.; Englmaier, F.; Böttcher, T. Competitive Live-Cell Profiling Strategy for Discovering Inhibitors of the Quinolone Biosynthesis of Pseudomonas aeruginosa. Journal of the American Chemical Society 2018, 140, 14019–14023. doi:10.1021/jacs.8b07629
  • Schütz, C.; Empting, M. Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers. Beilstein journal of organic chemistry 2018, 14, 2627–2645. doi:10.3762/bjoc.14.241
  • Sharifzadeh, S.; Shirley, J. D.; Carlson, E. E. Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles. Current topics in microbiology and immunology 2018, 420, 23–48. doi:10.1007/82_2018_135
  • Modi, A.; Sau, P.; Patel, B. K. Base-Promoted Synthesis of Quinoline-4(1H)-thiones from o-Alkynylanilines and Aroyl Isothiocyanates. Organic letters 2017, 19, 6128–6131. doi:10.1021/acs.orglett.7b02993
  • Leichnitz, D.; Raguž, L.; Beemelmanns, C. Total synthesis and functional analysis of microbial signalling molecules. Chemical Society reviews 2017, 46, 6330–6344. doi:10.1039/c6cs00665e
  • Kamal, A. A. M.; Maurer, C. K.; Allegretta, G.; Haupenthal, J.; Empting, M.; Hartmann, R. W. Quorum Sensing Inhibitors as Pathoblockers for Pseudomonas aeruginosa Infections: A New Concept in Anti-Infective Drug Discovery. Topics in Medicinal Chemistry; Springer International Publishing, 2017; pp 185–210. doi:10.1007/7355_2017_17

Patents

  • BÖTTCHER THOMAS; PROTHIWA MICHAELA; ENGLMAIER FELIX. COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTIONS. EP 3639816 A1, April 22, 2020.
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