Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

Scholarly Works

• Mobaraki, M.; Rahimpour, M. R. Reaction mediums and apparatus safety: reactors, columns, etc.. Crises in Oil, Gas and Petrochemical Industries; Elsevier, 2023; pp 159–176. doi:10.1016/b978-0-323-95163-0.00008-6
• Mor, S.; Khatri, M.; Punia, R.; Nagoria, S.; Sindhu, S. A New Insight into the Synthesis and Biological Activities of Pyrazole based Derivatives. Mini-Reviews in Organic Chemistry 2022, 19, 717–778. doi:10.2174/1570193x19666220118111614
• Kapase, V. S. Microwave Assisted Synthesis and QSAR Study of1-Substituted-3-aryl-1H-pyrazole-4-carbaldehydes Derivatives. Asian Journal of Organic & Medicinal Chemistry 2021, 6, 79–83. doi:10.14233/ajomc.2021.ajomc-p315
• Amii, H. Recent Advances in the Integrated Microflow Synthesis of Organofluorine Compounds. Middle Molecular Strategy; Springer Singapore, 2021; pp 331–357. doi:10.1007/978-981-16-2458-2_19
• Zhang, Q.; Dong, Z.; Zhao, S.; Liu, Z.; Chen, G. Ultrasound-assisted gas-liquid mass transfer process in microreactors: The influence of surfactant, channel size and ultrasound frequency. Chemical Engineering Journal 2021, 405, 126720. doi:10.1016/j.cej.2020.126720
• Zhu, R.; Reddy, R.; Ding, M.; Xu, M.; Deng, C.; Tadayon, S.; Li, H.; Depew, K. M.; Lane, B. S. Development and Scale-Up of a Continuous Manufacturing Process for a Hydrazine Condensation Reaction. Organic Process Research & Development 2021, 25, 199–205. doi:10.1021/acs.oprd.0c00424
• Scholtz, C.; Riley, D. L. Improved batch and flow syntheses of the nonsteroidal anti-inflammatory COX-2 inhibitor celecoxib. Reaction Chemistry & Engineering 2021, 6, 138–146. doi:10.1039/d0re00346h
• Chegeni, B. K. Microfluidics in organic chemistry. Biomedical Applications of Microfluidic Devices; Elsevier, 2021; pp 235–255. doi:10.1016/b978-0-12-818791-3.00011-5
• Westermeyer, A.; Guillamot, G.; Phansavath, P.; Ratovelomanana-Vidal, V. Electrophilic ring fluorination of 3,5-disubstituted pyrazoles: application to the formal synthesis of a neprilysin inhibitor key intermediate. New Journal of Chemistry 2020, 44, 20535–20543. doi:10.1039/d0nj05222a
• Neufeld, J.; Daniliuc, C. G.; Gilmour, R. Fluorohydration of alkynes via I(I)/I(III) catalysis. Beilstein journal of organic chemistry 2020, 16, 1627–1635. doi:10.3762/bjoc.16.135
• Brandão, P.; Pineiro, M.; Pinho e Melo, T. M. V. D. Flow Chemistry: Towards A More Sustainable Heterocyclic Synthesis. European Journal of Organic Chemistry 2019, 2019, 7188–7217. doi:10.1002/ejoc.201901335
• Kandasamy, M.; Ganesan, B.; Hung, M.-Y.; Lin, W.-Y. Fast and Efficient Continuous Flow Method for the Synthesis of Ynones and Pyrazoles. European Journal of Organic Chemistry 2019, 2019, 3183–3189. doi:10.1002/ejoc.201900468
• Reddy, N. S.; Kumar, N. R.; Swaroop, D. K.; Punna, N.; Dev, G. J.; Babu, N. J.; Narsaiah, B. Gem-Difluorination of Triazole Alkyl Functionalized Amino Pyrazoles by Selectfluor to Access 4,4-Difluoro-pyrazol-3-ones/Pyrazol-3-imines. European Journal of Organic Chemistry 2019, 2019, 2409–2413. doi:10.1002/ejoc.201900173
• Ötvös, S. B.; Georgiádes, Á.; Ozsvár, D.; Fülöp, F. Continuous-flow synthesis of 3,5-disubstituted pyrazoles via sequential alkyne homocoupling and Cope-type hydroamination. RSC advances 2019, 9, 8197–8203. doi:10.1039/c9ra01590f
• Hirano, K.; Gondo, S.; Punna, N.; Tokunaga, E.; Shibata, N. Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines. ChemistryOpen 2019, 8, 402. doi:10.1002/open.201900070
• Sato, K.; Sandford, G.; Konishi, Y.; Yanada, N.; Toda, C.; Tarui, A.; Omote, M. Lewis acid promoted fluorine-alkoxy group exchange reactions for the synthesis of 5-alkoxy-4,4-difluoroisoxazoline systems. Organic & biomolecular chemistry 2019, 17, 2818–2823. doi:10.1039/c9ob00097f
• Hirano, K.; Gondo, S.; Punna, N.; Tokunaga, E.; Shibata, N. Gas/Liquid‐Phase Micro‐Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N‐Sulfinylimines. ChemistryOpen 2019, 8, 406–410. doi:10.1002/open.201800286
• Rajesh, V.; Buwa, V. V. Volume-of-fluid simulations of gas-liquid-liquid flows in minichannels. Chemical Engineering Journal 2018, 345, 688–705. doi:10.1016/j.cej.2018.01.050
• Van Mileghem, S.; Veryser, C.; De Borggraeve, W. M. Flow-Assisted Synthesis of Heterocycles via Multicomponent Reactions. Topics in Heterocyclic Chemistry; Springer International Publishing, 2018; pp 133–159. doi:10.1007/7081_2018_23
• Rahman, T.; Wirth, T. Safe Use of Hazardous Chemicals in Flow. Topics in Heterocyclic Chemistry; Springer International Publishing, 2018; pp 343–373. doi:10.1007/7081_2018_17

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