TY - JOUR A1 - Jeliazkova, Nina A1 - Chomenidis, Charalampos A1 - Doganis, Philip A1 - Fadeel, Bengt A1 - Grafström, Roland A1 - Hardy, Barry A1 - Hastings, Janna A1 - Hegi, Markus A1 - Jeliazkov, Vedrin A1 - Kochev, Nikolay A1 - Kohonen, Pekka A1 - Munteanu, Cristian R. A1 - Sarimveis, Haralambos A1 - Smeets, Bart A1 - Sopasakis, Pantelis A1 - Tsiliki, Georgia A1 - Vorgrimmler, David A1 - Willighagen, Egon T1 - The eNanoMapper database for nanomaterial safety information JF - Beilstein Journal of Nanotechnology PY - 2015/// VL - 6 SP - 1609 EP - 1634 SN - 2190-4286 DO - 10.3762/bjnano.6.165 PB - Beilstein-Institut JA - Beilstein J. Nanotechnol. UR - https://doi.org/10.3762/bjnano.6.165 KW - database KW - EU NanoSafety Cluster KW - nanoinformatics KW - nanomaterials KW - nanomaterials ontology KW - NanoQSAR KW - safety testing N2 - Background: The NanoSafety Cluster, a cluster of projects funded by the European Commision, identified the need for a computational infrastructure for toxicological data management of engineered nanomaterials (ENMs). Ontologies, open standards, and interoperable designs were envisioned to empower a harmonized approach to European research in nanotechnology. This setting provides a number of opportunities and challenges in the representation of nanomaterials data and the integration of ENM information originating from diverse systems. Within this cluster, eNanoMapper works towards supporting the collaborative safety assessment for ENMs by creating a modular and extensible infrastructure for data sharing, data analysis, and building computational toxicology models for ENMs.Results: The eNanoMapper database solution builds on the previous experience of the consortium partners in supporting diverse data through flexible data storage, open source components and web services. We have recently described the design of the eNanoMapper prototype database along with a summary of challenges in the representation of ENM data and an extensive review of existing nano-related data models, databases, and nanomaterials-related entries in chemical and toxicogenomic databases. This paper continues with a focus on the database functionality exposed through its application programming interface (API), and its use in visualisation and modelling. Considering the preferred community practice of using spreadsheet templates, we developed a configurable spreadsheet parser facilitating user friendly data preparation and data upload. We further present a web application able to retrieve the experimental data via the API and analyze it with multiple data preprocessing and machine learning algorithms.Conclusion: We demonstrate how the eNanoMapper database is used to import and publish online ENM and assay data from several data sources, how the “representational state transfer” (REST) API enables building user friendly interfaces and graphical summaries of the data, and how these resources facilitate the modelling of reproducible quantitative structure–activity relationships for nanomaterials (NanoQSAR). ER -