TY - JOUR A1 - Liu, Rong A1 - Ge, Yuan A1 - Holden, Patricia A. A1 - Cohen, Yoram T1 - Analysis of soil bacteria susceptibility to manufactured nanoparticles via data visualization JF - Beilstein Journal of Nanotechnology PY - 2015/// VL - 6 SP - 1635 EP - 1651 SN - 2190-4286 DO - 10.3762/bjnano.6.166 PB - Beilstein-Institut JA - Beilstein J. Nanotechnol. UR - https://doi.org/10.3762/bjnano.6.166 KW - environmental impact KW - manufactured nanoparticles KW - nanoinformatics KW - soil bacteria KW - visualization N2 - The impact of ZnO and TiO2 manufactured nanoparticles (MNPs) on soil bacterial communities for different exposure periods and MNP doses was explored via data visualization techniques. Interrelationships between MNP treatments and responses of bacterial taxa were illustrated by bipartite graphs, allowing fast identification of important soil bacterial taxa that are susceptible to MNPs. Contribution biplots with subcompositional coherence property were generated via log-ratio analysis (LRA), which jointly display the treatment distribution and the variance (contribution) of bacterial taxa. The LRA contribution biplots and nonmetric multi-dimensional scaling (NMDS) of the dataset, along with hierarchical clustering, demonstrated that high doses of ZnO and TiO2 MNPs caused significant compositional changes in soil bacterial communities. The suitability of family level for MNP taxonomic impact assessment was demonstrated by both the LRA biplots and simplified NMDSs with quantification provided by the distance correlation between MNP impacts summarized at different taxonomic levels. The present study demonstrates that visual exploration could potentially assist in knowledge discovery and interpretation of data on soil bacterial communities exposed to MNPs and thus evaluate the potential for environmental impacts. ER -