TY - JOUR A1 - Hrib, Jakub A1 - Sirc, Jakub A1 - Hobzova, Radka A1 - Hampejsova, Zuzana A1 - Bosakova, Zuzana A1 - Munzarova, Marcela A1 - Michalek, Jiri T1 - Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure JF - Beilstein Journal of Nanotechnology PY - 2015/// VL - 6 SP - 1939 EP - 1945 SN - 2190-4286 DO - 10.3762/bjnano.6.198 PB - Beilstein-Institut JA - Beilstein J. Nanotechnol. UR - https://doi.org/10.3762/bjnano.6.198 KW - nanofibers KW - nanofibrous carriers KW - needle-free electrospinning KW - release kinetics N2 - Nanofibers were prepared from polycaprolactone, polylactide and polyvinyl alcohol using NanospiderTM technology. Polyethylene glycols with molecular weights of 2 000, 6 000, 10 000 and 20 000 g/mol, which can be used to moderate the release profile of incorporated pharmacologically active compounds, served as model molecules. They were terminated by aromatic isocyanate and incorporated into the nanofibers. The release of these molecules into an aqueous environment was investigated. The influences of the molecular length and chemical composition of the nanofibers on the release rate and the amount of released polyethylene glycols were evaluated. Longer molecules released faster, as evidenced by a significantly higher amount of released molecules after 72 hours. However, the influence of the chemical composition of nanofibers was even more distinct – the highest amount of polyethylene glycol molecules released from polyvinyl alcohol nanofibers, the lowest amount from polylactide nanofibers. ER -