TY - JOUR A1 - Pop-Georgievski, Ognen A1 - Kubies, Dana A1 - Zemek, Josef A1 - Neykova, Neda A1 - Demianchuk, Roman A1 - Chánová, Eliška Mázl A1 - Šlouf, Miroslav A1 - Houska, Milan A1 - Rypáček, František T1 - Self-assembled anchor layers/polysaccharide coatings on titanium surfaces: a study of functionalization and stability JF - Beilstein Journal of Nanotechnology PY - 2015/// VL - 6 SP - 617 EP - 631 SN - 2190-4286 DO - 10.3762/bjnano.6.63 PB - Beilstein-Institut JA - Beilstein J. Nanotechnol. UR - https://doi.org/10.3762/bjnano.6.63 KW - alginate KW - biomimetic surfaces KW - bisphosphonates KW - neridronate KW - poly(dopamine) KW - spectroscopic ellipsometry KW - surface characterization KW - surface modification KW - titanium KW - XPS N2 - Composite materials based on a titanium support and a thin, alginate hydrogel could be used in bone tissue engineering as a scaffold material that provides biologically active molecules. The main objective of this contribution is to characterize the activation and the functionalization of titanium surfaces by the covalent immobilization of anchoring layers of self-assembled bisphosphonate neridronate monolayers and polymer films of 3-aminopropyltriethoxysilane and biomimetic poly(dopamine). These were further used to bind a bio-functional alginate coating. The success of the titanium surface activation, anchoring layer formation and alginate immobilization, as well as the stability upon immersion under physiological-like conditions, are demonstrated by different surface sensitive techniques such as spectroscopic ellipsometry, infrared reflection–absorption spectroscopy and X-ray photoelectron spectroscopy. The changes in morphology and the established continuity of the layers are examined by scanning electron microscopy, surface profilometry and atomic force microscopy. The changes in hydrophilicity after each modification step are further examined by contact angle goniometry. ER -