TY - JOUR A1 - Hynek, Jan A1 - Jurík, Sebastian A1 - Koncošová, Martina A1 - Zelenka, Jaroslav A1 - Křížová, Ivana A1 - Ruml, Tomáš A1 - Kirakci, Kaplan A1 - Jakubec, Ivo A1 - Kovanda, František A1 - Lang, Kamil A1 - Demel, Jan T1 - The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy JF - Beilstein Journal of Nanotechnology PY - 2018/// VL - 9 SP - 2960 EP - 2967 SN - 2190-4286 DO - 10.3762/bjnano.9.275 PB - Beilstein-Institut JA - Beilstein J. Nanotechnol. UR - https://doi.org/10.3762/bjnano.9.275 KW - metal-organic framework KW - phosphinic acid based MOF KW - photodynamic therapy KW - porphyrin KW - singlet oxygen N2 - Nanosized porphyrin-containing metal-organic frameworks (MOFs) attract considerable attention as solid-state photosensitizers for biological applications. In this study, we have for the first time synthesised and characterised phosphinate-based MOF nanoparticles, nanoICR-2 (Inorganic Chemistry Rez). We demonstrate that nanoICR-2 can be decorated with anionic 5,10,15,20-tetrakis(4-R-phosphinatophenyl)porphyrins (R = methyl, isopropyl, phenyl) by utilizing unsaturated metal sites on the nanoparticle surface. The use of these porphyrins allows for superior loading of the nanoparticles when compared with commonly used 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin. The nanoICR-2/porphyrin composites retain part of the free porphyrins photophysical properties, while the photodynamic efficacy is strongly affected by the R substituent at the porphyrin phosphinate groups. Thus, phosphinatophenylporphyrin with phenyl substituents has the strongest photodynamic efficacy due to the most efficient cellular uptake. ER -