1 article(s) from Kolosov, Maksim A.
- Full Research Paper
- Published 08 Mar 2021
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Graphical Abstract
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Figure 1: Benzodiazepine-based azolo-containing drugs.
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Figure 2: Novel potential 1,2,3-triazolobenziadiazepine drugs.
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Scheme 1: Examples of synthesis of 1,2,3-triazolobenzodiazepines via tandem approach Ugi reaction/IAAC. Reage...
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Scheme 2: Azide precursor synthesis.
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Scheme 3: Synthesis of Ugi products 6, their structures and yields.
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Figure 3: Code legend for Ugi products 6 and molecular structure (X-ray analysis) of compound 6aaa.
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Scheme 4: Cyclization of Ugi-product 6aab with terminal alkyne fragment.
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Figure 4: 1H NMR spectra of the reactant and the product of IAAC.
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Figure 5: Molecular structure of compound 7aaa (X-ray analysis) and comparison of 1H NMR spectra of compounds ...
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Scheme 5: The substrate scope of intermolecular cycloaddition.
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