1 article(s) from Konno, Hiroyuki
- Full Research Paper
- Published 29 Oct 2020
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Graphical Abstract
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Figure 1: Anti-HIV compound containing a trifluoromethylpropargylamine moiety.
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Scheme 1: Literature-known methods (a and b) and the here reported (c) approach for the synthesis of α-triflu...
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Scheme 2: Substrate scope study. Reaction conditions: arylethyne 2 (0.39 mmol), imine 1 (0.3 mmol), LiHMDS (0...
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Figure 2: ORTEP diagram showing of the minor product of 3a.
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Figure 3: Mode of nucleophilic attacks A and B.
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Scheme 3: Large-scale application of the reaction.
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Scheme 4: Removal of the chiral auxiliary.
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