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1 article(s) from Laongthipparos, Cherdchai

Synthesis of 3-aminocoumarin-N-benzylpyridinium conjugates with nanomolar inhibitory activity against acetylcholinesterase

Nisachon Khunnawutmanotham,
Cherdchai Laongthipparos,
Patchreenart Saparpakorn,
Nitirat Chimnoi and
Supanna Techasakul

Full Research Paper
Published 02 Oct 2018

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1. Graphical Abstract
2. Figure 1: Design of the target compounds.
  
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3. Scheme 1: Synthesis of 3-aminocoumarin-N-benzylpyridinium salts.
  
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4. Figure 2: Docked conformations of donepezil (ball-and-stick model; pink), compounds 9a, 9b, 9e, 9h, and 9i (s...
  
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5. Figure 3: Binding interactions in the rhAChE binding pocket with (a) 4a, (b) 9a, (c) 9b, (d) 9e, (e) 9h, (f) ...
  
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Graphical Abstract

Beilstein J. Org. Chem. 2018, 14, 2545–2552, doi:10.3762/bjoc.14.231

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