Author

3 article(s) from Saito, Norimichi

Deoxyfluorination of acyl fluorides to trifluoromethyl compounds by FLUOLEAD^®/Olah’s reagent under solvent-free conditions

Yumeng Liang,
Akihito Taya,
Zhengyu Zhao,
Norimichi Saito and
Norio Shibata

Letter
Published 14 Dec 2020

PDF
Album
1. Graphical Abstract
2. Figure 1: Ratios of CF₃-containing drugs in marketed fluoro-pharmaceuticals and registered fluoro-agrochemica...
  
  Jump to Figure 1
3. Figure 2: Selected examples of CF₃-containing biologically active molecules.
  
  Jump to Figure 2
4. Scheme 1: Transformation of acyl fluorides to trifluoromethyl compounds. a) Deoxyfluorination of acyl fluorid...
  
  Jump to Scheme 1
5. Scheme 2: The substrate scope of acyl fluorides. Reaction conditions: 1 (0.3 mmol), FLUOLEAD^® (0.9 mmol, 3.0 ...
  
  Jump to Scheme 2
6. Scheme 3: Mechanism of deoxyfluorination of acyl fluorides 1 with FLUOLEAD^®/Olah’s reagent to trifluoromethyl...
  
  Jump to Scheme 3
Supp. Info

Beilstein J. Org. Chem. 2020, 16, 3052–3058, doi:10.3762/bjoc.16.254

Full Text

Synthesis of fluoro-functionalized diaryl-λ³-iodonium salts and their cytotoxicity against human lymphoma U937 cells

Prajwalita Das,
Etsuko Tokunaga,
Hidehiko Akiyama,
Hiroki Doi,
Norimichi Saito and
Norio Shibata

Full Research Paper
Published 07 Feb 2018

PDF
Album
1. Graphical Abstract
2. Figure 1: Compounds used for the biological study.
  
  Jump to Figure 1
3. Figure 2: Compounds 1–4 induced cell death in U937 cells. Briefly, U937 cells (1 × 10⁴ cells/mL) were incubat...
  
  Jump to Figure 2
4. Scheme 1: Synthesis of pentafluoro-(2-iodophenyl)-λ⁶-sulfane (7).
  
  Jump to Scheme 1
5. Scheme 2: Synthesis of unsymmetrical ortho-SF₅ diaryliodonium salts 3p, 4b, 5a and 6a.
  
  Jump to Scheme 2
6. Figure 3: X-ray crystallographic structure of 3p drawn at 50% probability (CCDC 1573953).
  
  Jump to Figure 3
7. Figure 4: Ortho-SF₅ phenyl iodonium salts 3p and 5a and their structural components 7 and 9 induced cell deat...
  
  Jump to Figure 4
8. Figure 5: 3k, 3m and 3p induced cell death in AGLCL, a human normal B cell line. Briefly, AGLCL cells (1 × 10⁴...
  
  Jump to Figure 5
Supp. Info

Beilstein J. Org. Chem. 2018, 14, 364–372, doi:10.3762/bjoc.14.24

Full Text

Discovery of practical production processes for arylsulfur pentafluorides and their higher homologues, bis- and tris(sulfur pentafluorides): Beginning of a new era of “super-trifluoromethyl” arene chemistry and its industry

Teruo Umemoto,
Lloyd M. Garrick and
Norimichi Saito

Full Research Paper
Published 29 Mar 2012

PDF
Album
1. Graphical Abstract
2. Scheme 1: Preparation of ArSF₄Cl 2.
  
  Jump to Scheme 1
3. Scheme 2: Preparation of Ar(SF₄Cl)_n from Ar(SH)_n (n = 2, 3).
  
  Jump to Scheme 2
4. Scheme 3: Reaction mechanism for the formation of ArSF₄Cl.
  
  Jump to Scheme 3
5. Scheme 4: Reaction mechanism for the formation of trans and cis-ArSF₄Cl.
  
  Jump to Scheme 4
6. Scheme 5: Preparation of ArSF₅ with ZnF₂.
  
  Jump to Scheme 5
7. Scheme 6: Preparation of PhSF₅ with anhydrous HF.
  
  Jump to Scheme 6
8. Scheme 7: Preparation of 3a with HF–pyridine.
  
  Jump to Scheme 7
9. Scheme 8: Preparation of polyfluorinated ArSF₅.
  
  Jump to Scheme 8
10. Scheme 9: Preparation of aryl bis- and tris(sulfur pentafluorides), Ar(SF₅)_n (n = 2,3).
  
  Jump to Scheme 9
Supp. Info

Beilstein J. Org. Chem. 2012, 8, 461–471, doi:10.3762/bjoc.8.53

Full Text

Other Beilstein-Institut Open Science Activities

Keep Informed

RSS Feed

Subscribe to our Latest Articles RSS Feed.

Subscribe

Email Notification

Register and get informed about new articles.

Register

Follow the Beilstein-Institut

Twitter: @BeilsteinInst