3 article(s) from Wittmann, Valentin
Cyclopropene-modified mannosamine, glucosamine and galactosamine derivatives employed for MGE.
Jump to Figure 1
A) Reaction of ManNCyc and ManNCp, respectively, with Tz-PEG-OH to determine second-order rate cons...
Jump to Figure 2
MGE with cyclopropene-modified mannosamines. Cells were grown with sugar for 48 hours and then incu...
Jump to Scheme 1
HEK 293T cells were grown with 100 μM Ac4ManNCyc, Ac4ManNCp, Ac4ManNCyoc or DMSO only (negative con...
Jump to Figure 3
Synthesis of Ac4ManNCp(H2) and Ac4ManNCyc(H2) and the corresponding DMB-labeled sialic acids. C/A =...
Jump to Scheme 2
Synthesis of Ac4ManNCyoc(H2) and the corresponding DMB-labeled sialic acid.
Jump to Scheme 3
Synthesis of Ac4GlcNCp and Ac4GalNCp.
Jump to Scheme 4
HEK 293T cells were grown with 100 μM Ac4ManNCp, Ac4GlcNCp, Ac4GalNCp or DMSO only (negative contro...
Jump to Figure 4
HEK 293T cells were grown with 100 μM Ac4GlcNCp, Ac4GalNCp or DMSO only (negative control) for 48 h...
Jump to Figure 5
HEK 293T cells were grown with 50 μM (A) or 100 μM (B) Ac4GlcNCp, Ac4GlcNCyoc or DMSO only (negativ...
Jump to Figure 6
Western blot analysis of soluble glycoproteins. HEK 293T cells were grown for 48 h with 100 μM Ac4M...
Jump to Figure 7
Synthesis of Ac4GlcNCp(H2) and Ac4GlcNCyoc(H2).
Jump to Scheme 5
Beilstein J. Org. Chem. 2019, 15, 584–601, doi:10.3762/bjoc.15.54
Principle of MOE with Ac4GlcNCyoc (1) and subsequent ligation by a DAinv reaction: The chemically m...
Hexosamine derivatives with cyclopropene tags. Cyoc = (2-methylcycloprop-2-en-1-yl)methoxycarbonyl,...
Synthesis of the cyclopropene-modified hexosamine derivatives 1 and 2.
Labeling strategy for metabolically incorporated monosaccharides.
Labeling of metabolically engineered cell-surface glycoconjugates. HEK 293T cells were grown for 48...
Western blot analysis of soluble glycoproteins. HeLa S3 cells were grown for 48 h with 100 µM cyclo...
Beilstein J. Org. Chem. 2014, 10, 2235–2242, doi:10.3762/bjoc.10.232
Amines used for the synthesis of glycoclusters.
Synthesis of glycocluster B5 with isolation of the intermediate diazide 2.
Deacetylation of glycoconjugates B1–B6. (a) NaOMe, MeOH.
Formation of side-product 5 during the synthesis of 4.
Dose-response curves for the inhibition of binding of HRP-labeled WGA to covalently immobilized Glc...
Molecular model of divalent ligand C4 with its two chitobiose moieties occupying two adjacent bindi...
Beilstein J. Org. Chem. 2012, 8, 819–826, doi:10.3762/bjoc.8.91
Subscribe to our Latest Articles RSS Feed.
Register and get informed about new articles.
Follow the Beilstein-Institut