TY - JOUR A1 - Rabe, Sebastian A1 - Moschner, Johann A1 - Bantzi, Marina A1 - Heretsch, Philipp A1 - Giannis, Athanassios T1 - C–H-Functionalization logic guides the synthesis of a carbacyclopamine analog JF - Beilstein Journal of Organic Chemistry PY - 2014/// VL - 10 SP - 1564 EP - 1569 SN - 1860-5397 DO - 10.3762/bjoc.10.161 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.10.161 KW - cyclopamine KW - C–H-functionalization KW - hedgehog signaling pathway KW - natural products KW - steroidal alkaloids N2 - The chemical synthesis of carbacyclopamine analog 2, a cyclopamine analog with an all-carbon E-ring, is reported. The use of C–H-functionalization logic and further metal-catalyzed transformations allows for a concise entry to this new class of acid-stable cyclopamine analogs. ER -