TY - JOUR A1 - Focken, Thilo A1 - Hanessian, Stephen T1 - Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules JF - Beilstein Journal of Organic Chemistry PY - 2014/// VL - 10 SP - 1848 EP - 1877 SN - 1860-5397 DO - 10.3762/bjoc.10.195 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.10.195 KW - conjugate addition KW - cyclopropanation KW - olefination KW - organophosphorus KW - phosphonamide KW - total synthesis N2 - A review of the synthesis of natural products and bioactive compounds adopting phosphonamide anion technology is presented highlighting the utility of phosphonamide reagents in stereocontrolled bond-forming reactions. Methodologies utilizing phosphonamide anions in asymmetric alkylations, Michael additions, olefinations, and cyclopropanations will be summarized, as well as an overview of the synthesis of the employed phosphonamide reagents. ER -