TY - JOUR A1 - Kucukdisli, Murat A1 - Ferenc, Dorota A1 - Heinz, Marcel A1 - Wiebe, Christine A1 - Opatz, Till T1 - Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones JF - Beilstein Journal of Organic Chemistry PY - 2014/// VL - 10 SP - 466 EP - 470 SN - 1860-5397 DO - 10.3762/bjoc.10.44 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.10.44 KW - α-aminonitriles KW - cyclization KW - heterocycles KW - microwave-assisted synthesis KW - pyrroles N2 - The cyclocondensation of enones with aminoacetonitrile furnishes 3,4-dihydro-2H-pyrrole-2-carbonitriles which can be readily converted to 2,4-disubstituted pyrroles by microwave-induced dehydrocyanation. Alternatively, oxidation of the intermediates produces 3,5-disubstituted pyrrole-2-carbonitriles. ER -