TY - JOUR A1 - Johnson, Tarn C. A1 - Marsden, Stephen P. T1 - A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines JF - Beilstein Journal of Organic Chemistry PY - 2016/// VL - 12 SP - 1 EP - 4 SN - 1860-5397 DO - 10.3762/bjoc.12.1 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.12.1 KW - azlactones KW - pyridines KW - pyridine N-oxides KW - substitution N2 - A convenient, one-pot, two-component synthesis of 2-(1-amidoalkyl)pyridines is reported, based upon the substitution of suitably-activated pyridine N-oxides by azlactone nucleophiles, followed by decarboxylative azlactone ring-opening. The synthesis obviates the need for precious metal catalysts to achieve a formal enolate arylation reaction, and constitutes a formally ‘umpoled’ approach to this valuable class of bioactive structures. ER -