TY - JOUR A1 - Jakubec, Pavol A1 - Farley, Alistair J. M. A1 - Dixon, Darren J. T1 - Towards the total synthesis of keramaphidin B JF - Beilstein Journal of Organic Chemistry PY - 2016/// VL - 12 SP - 1096 EP - 1100 SN - 1860-5397 DO - 10.3762/bjoc.12.104 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.12.104 KW - bifunctional organocatalyst KW - enantioselective Michael addition KW - keramaphidin B KW - nitro-Mannich lactamisation cascade N2 - The enantio- and diastereoselective Michael addition of a δ-valerolactone-derived pronucleophile to a substituted furanyl nitroolefin catalysed by a bifunctional cinchonine-derived thiourea has been used as the key stereocontrolling step in a new synthetic strategy to the heavily functionalised piperidine core of keramaphidin B. ER -