TY - JOUR A1 - Atkinson, Darcy J. A1 - Naysmith, Briar J. A1 - Furkert, Daniel P. A1 - Brimble, Margaret A. T1 - Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis JF - Beilstein Journal of Organic Chemistry PY - 2016/// VL - 12 SP - 2325 EP - 2342 SN - 1860-5397 DO - 10.3762/bjoc.12.226 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.12.226 KW - amino acid KW - bacterial resistance KW - enduracididine KW - natural products KW - peptide antibiotics N2 - Rising resistance to current clinical antibacterial agents is an imminent threat to global public health and highlights the demand for new lead compounds for drug discovery. One such potential lead compound, the peptide antibiotic teixobactin, was recently isolated from an uncultured bacterial source, and demonstrates remarkably high potency against a wide range of resistant pathogens without apparent development of resistance. A rare amino acid residue component of teixobactin, enduracididine, is only known to occur in a small number of natural products that also possess promising antibiotic activity. This review highlights the presence of enduracididine in natural products, its biosynthesis together with a review of analogues of enduracididine. Reported synthetic approaches to the cyclic guanidine structure of enduracididine are discussed, illustrating the challenges encountered to date in the development of efficient synthetic routes to facilitate drug discovery efforts inspired by the discovery of teixobactin. ER -