TY - JOUR A1 - Pessel, Freddy A1 - Augé, Jacques A1 - Billault, Isabelle A1 - Scherrmann, Marie-Christine T1 - The weight of flash chromatography: A tool to predict its mass intensity from thin-layer chromatography JF - Beilstein Journal of Organic Chemistry PY - 2016/// VL - 12 SP - 2351 EP - 2357 SN - 1860-5397 DO - 10.3762/bjoc.12.228 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.12.228 KW - environmental factor KW - flash chromatography KW - green metrics KW - mass intensity KW - purification N2 - Purification by flash chromatography strongly impacts the greenness of a process. Unfortunately, due to the lack of the relevant literature data, very often this impact cannot be assessed thus preventing the comparison of the environmental factors affecting the syntheses. We developed a simple mathematical approach to evaluate the minimum mass intensity of flash chromatography from the retention factor values determined by thin-layer chromatography. ER -