TY - JOUR A1 - Porta, Riccardo A1 - Puglisi, Alessandra A1 - Colombo, Giacomo A1 - Rossi, Sergio A1 - Benaglia, Maurizio T1 - Continuous-flow synthesis of primary amines: Metal-free reduction of aliphatic and aromatic nitro derivatives with trichlorosilane JF - Beilstein Journal of Organic Chemistry PY - 2016/// VL - 12 SP - 2614 EP - 2619 SN - 1860-5397 DO - 10.3762/bjoc.12.257 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.12.257 KW - chemoselectivity KW - continuous processes KW - flow synthesis KW - nitro reduction KW - trichlorosilane N2 - The metal-free reduction of nitro compounds to amines mediated by trichlorosilane was successfully performed for the first time under continuous-flow conditions. Aromatic as well as aliphatic nitro derivatives were converted to the corresponding primary amines in high yields and very short reaction times with no need for purification. The methodology was also extended to the synthesis of two synthetically relevant intermediates (precursors of baclofen and boscalid). ER -