TY - JOUR A1 - Querard, Pierre A1 - Perepichka, Inna A1 - Zysman-Colman, Eli A1 - Li, Chao-Jun T1 - Copper-catalyzed asymmetric sp3 C–H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst JF - Beilstein Journal of Organic Chemistry PY - 2016/// VL - 12 SP - 2636 EP - 2643 SN - 1860-5397 DO - 10.3762/bjoc.12.260 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.12.260 KW - C–H arylation KW - copper catalyst KW - enantioselectivity KW - visible light N2 - This report describes a highly enantioselective oxidative sp3 C–H arylation of N-aryltetrahydroisoquinolines (THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir(ppy)2(dtbbpy)]PF6, and chiral copper catalysts provide a mild and highly effective sp3 C–H asymmetric arylation of THIQs. ER -