TY - JOUR A1 - Zhang, Hong-Bo A1 - Luo, Yong-Chun A1 - Hu, Xiu-Qin A1 - Liang, Yong-Min A1 - Xu, Peng-Fei T1 - A quadruple cascade protocol for the one-pot synthesis of fully-substituted hexahydroisoindolinones from simple substrates JF - Beilstein Journal of Organic Chemistry PY - 2016/// VL - 12 SP - 253 EP - 259 SN - 1860-5397 DO - 10.3762/bjoc.12.27 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.12.27 KW - bifunctional catalysis KW - hexahydroisoindolinones KW - one-pot synthesis KW - quadruple cascade N2 - A new and efficient synthetic method to obtain fully-substituted hexahydroisoindolinones was developed by using bifunctional tertiary amine-thioureas as powerful catalysts. As far as we know, there is no efficient synthetic method developed toward fully-substituted hexahydroisoindolinones. The products were obtained in good yield and diastereoselectivity. The one-pot cascade quadruple protocol features readily available starting materials, simple manipulation, mild conditions and good atom economy. ER -