TY - JOUR A1 - Zhang, Ming-Liang A1 - Yue, Deng-Feng A1 - Wang, Zhen-Hua A1 - Luo, Yuan A1 - Xu, Xiao-Ying A1 - Zhang, Xiao-Mei A1 - Yuan, Wei-Cheng T1 - Organocatalytic asymmetric Henry reaction of 1H-pyrrole-2,3-diones with bifunctional amine-thiourea catalysts bearing multiple hydrogen-bond donors JF - Beilstein Journal of Organic Chemistry PY - 2016/// VL - 12 SP - 295 EP - 300 SN - 1860-5397 DO - 10.3762/bjoc.12.31 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.12.31 KW - asymmetric catalysis KW - bifunctional catalysts KW - Henry reaction KW - organocatalysis KW - 1H-pyrrole-2,3-diones N2 - For the first time, a catalytic asymmetric Henry reaction of 1H-pyrrole-2,3-diones was achieved with a chiral bifunctional amine-thiourea as a catalyst possessing multiple hydrogen-bond donors. With this developed method, a range of 3-hydroxy-3-nitromethyl-1H-pyrrol-2(3H)-ones bearing quaternary stereocenters were obtained in acceptable yield (up to 75%) and enantioselectivity (up to 73% ee). ER -