TY - JOUR A1 - Masui, Hisashi A1 - Yosugi, Sae A1 - Fuse, Shinichiro A1 - Takahashi, Takashi T1 - Solution-phase automated synthesis of an α-amino aldehyde as a versatile intermediate JF - Beilstein Journal of Organic Chemistry PY - 2017/// VL - 13 SP - 106 EP - 110 SN - 1860-5397 DO - 10.3762/bjoc.13.13 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.13.13 KW - acetal formation KW - amino acid KW - automated synthesis KW - Garner’s aldehyde KW - reduction N2 - A solution-phase automated synthesis of the versatile synthetic intermediate, Garner’s aldehyde, was demonstrated. tert-Butoxycarbonyl (Boc) protection, acetal formation, and reduction of the ester to the corresponding aldehyde were performed utilizing our originally developed automated synthesizer, ChemKonzert. The developed procedure was also useful for the synthesis of Garner’s aldehyde analogues possessing fluorenylmethyloxycarbonyl (Fmoc) or benzyloxycarbonyl (Cbz) protection. ER -