TY - JOUR A1 - Berini, Christophe A1 - Martin, Thibaut A1 - Lassalas, Pierrik A1 - Marsais, Francis A1 - Baudequin, Christine A1 - Hoarau, Christophe T1 - Synthesis of the heterocyclic core of the D-series GE2270 JF - Beilstein Journal of Organic Chemistry PY - 2017/// VL - 13 SP - 1407 EP - 1412 SN - 1860-5397 DO - 10.3762/bjoc.13.137 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.13.137 KW - antibiotic KW - bromination KW - BSC KW - C–H arylation KW - cross-coupling KW - Hantzsch synthesis KW - thiopeptide N2 - A straightforward enantiomerically pure synthesis of the heterocyclic core of the D-series GE2270 is reported. The synthetic strategy combines the Hantzsch thiazole’s building condensation with a cross-coupling reaction including direct C–H hetarylation to build and connect step-by-step thiazolyl moieties to the 5-bromopicolinate as readily available starting material. ER -