TY - JOUR A1 - Howard, Joseph L. A1 - Nicholson, William A1 - Sagatov, Yerbol A1 - Browne, Duncan L. T1 - One-pot multistep mechanochemical synthesis of fluorinated pyrazolones JF - Beilstein Journal of Organic Chemistry PY - 2017/// VL - 13 SP - 1950 EP - 1956 SN - 1860-5397 DO - 10.3762/bjoc.13.189 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.13.189 KW - fluorination KW - heterocycles KW - mechanochemistry KW - multistep KW - solid-state synthesis N2 - Solventless mechanochemical synthesis represents a technique with improved sustainability metrics compared to solvent-based processes. Herein, we describe a methodical process to run one solventless reaction directly into another through multistep mechanochemistry, effectively amplifying the solvent savings. The approach has to consider the solid form of the materials and compatibility of any auxiliary used. This has culminated in the development of a two-step, one-jar protocol for heterocycle formation and subsequent fluorination that has been successfully applied across a range of substrates, resulting in 12 difluorinated pyrazolones in moderate to excellent yields. ER -