TY - JOUR A1 - Wallbaum, Jan A1 - Werz, Daniel B. T1 - Synthesis of 1,3-cis-disubstituted sterically encumbered imidazolidinone organocatalysts JF - Beilstein Journal of Organic Chemistry PY - 2017/// VL - 13 SP - 2577 EP - 2583 SN - 1860-5397 DO - 10.3762/bjoc.13.254 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.13.254 KW - imidazolidinone KW - MacMillan catalyst KW - organocatalysis N2 - A variety of novel imidazolidinone-based organocatalysts with bulky substituents were synthesized under mild reaction conditions starting from easily accessible substrates. Different natural and unnatural amino acid methyl amides were cyclized with aromatic carbaldehydes to yield two diastereomeric MacMillan-type catalysts. Special emphasis was put on bulky residues such as mesityl and pyrene moieties. ER -