TY - JOUR A1 - Fan, Tao A1 - Meng, Wei-Dong A1 - Zhang, Xingang T1 - Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides JF - Beilstein Journal of Organic Chemistry PY - 2017/// VL - 13 SP - 2610 EP - 2616 SN - 1860-5397 DO - 10.3762/bjoc.13.258 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.13.258 KW - alkenes KW - cross-coupling KW - Heck-type reaction KW - palladium KW - secondary trifluoromethylated alkyl bromides N2 - An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl and hydroxy groups. Preliminary mechanistic studies reveal that a secondary trifluoromethylated alkyl radical is involved in the reaction. ER -