TY - JOUR A1 - Mascitti, Andrea A1 - Lupacchini, Massimiliano A1 - Guerra, Ruben A1 - Taydakov, Ilya A1 - Tonucci, Lucia A1 - d’Alessandro, Nicola A1 - Lamaty, Frederic A1 - Martinez, Jean A1 - Colacino, Evelina T1 - Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins JF - Beilstein Journal of Organic Chemistry PY - 2017/// VL - 13 SP - 19 EP - 25 SN - 1860-5397 DO - 10.3762/bjoc.13.3 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.13.3 KW - ball-milling KW - 1,1’-carbonyldiimidazole (CDI) KW - hydantoins KW - mechanochemistry KW - liquid-assisted grinding (LAG) KW - poly(ethylene) glycols (PEGs) N2 - The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures. ER -