TY - JOUR A1 - Verlee, Arno A1 - Heugebaert, Thomas A1 - van der Meer, Tom A1 - Kerchev, Pavel I. A1 - Van Breusegem, Frank A1 - Stevens, Christian V. T1 - A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues JF - Beilstein Journal of Organic Chemistry PY - 2017/// VL - 13 SP - 303 EP - 312 SN - 1860-5397 DO - 10.3762/bjoc.13.33 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.13.33 KW - flow chemistry KW - medium-throughput synthesis KW - m-sulfamoylbenzamide analogues N2 - For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are known for their bioactivity, a chemoselective procedure has been developed starting from m-(chlorosulfonyl)benzoyl chloride. Although a chemoselective process in batch was already reported, a continuous-flow process reveals an increased selectivity at higher temperatures and without catalysts. In total, 15 analogues were synthesized, using similar conditions, with yields ranging between 65 and 99%. This is the first automated and chemoselective synthesis of m-sulfamoylbenzamide analogues. ER -