TY - JOUR A1 - Wesche, Frank A1 - He, Yue A1 - Bode, Helge B. T1 - Solid-phase enrichment and analysis of electrophilic natural products JF - Beilstein Journal of Organic Chemistry PY - 2017/// VL - 13 SP - 405 EP - 409 SN - 1860-5397 DO - 10.3762/bjoc.13.43 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.13.43 KW - azides KW - click chemistry KW - enrichment KW - electrophilic natural products KW - epoxides KW - glidobactin KW - Photorhabdus KW - stilbenes N2 - In search for new natural products, which may lead to the development of new drugs for all kind of applications, novel methods are needed. Here we describe the identification of electrophilic natural products in crude extracts via their reactivity against azide as a nucleophile followed by their subsequent enrichment using a cleavable azide-reactive resin (CARR). Using this approach, natural products carrying epoxides and α,β-unsaturated enones as well as several unknown compounds were identified in crude extracts from entomopathogenic Photorhabdus bacteria. ER -