TY - JOUR A1 - Li, Dandan A1 - Oku, Naoya A1 - Hasada, Atsumi A1 - Shimizu, Masafumi A1 - Igarashi, Yasuhiro T1 - Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum, produced by a rhizobacterium of the genus Burkholderia sp. JF - Beilstein Journal of Organic Chemistry PY - 2018/// VL - 14 SP - 1446 EP - 1451 SN - 1860-5397 DO - 10.3762/bjoc.14.122 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.14.122 KW - antimicrobial KW - Burkholderia KW - quinolone KW - skin ulcer KW - Tenacibaculum maritimum N2 - Exploration of rhizobacteria of the genus Burkholderia as an under-tapped resource of bioactive molecules resulted in the isolation of two new antimicrobial 2-alkyl-4-quinolones. (E)-2-(Hept-2-en-1-yl)quinolin-4(1H)-one (1) and (E)-2-(non-2-en-1-yl)quinolin-4(1H)-one (3) were isolated from the culture broth of strain MBAF1239 together with four known alkylquinolones (2 and 4–6), pyrrolnitrin (7), and BN-227 (8). The structures of 1 and 3 were unambiguously characterized using NMR spectroscopy and mass spectrometry. Compounds 1–8 inhibited the growth of the marine bacterium Tenacibaculum maritimum, an etiological agent of skin ulcers in marine fish, offering new opportunities to develop antibacterial drugs for fish farming. ER -