TY - JOUR A1 - Barta, Petra A1 - Fülöp, Ferenc A1 - Szatmári, István T1 - Mannich base-connected syntheses mediated by ortho-quinone methides JF - Beilstein Journal of Organic Chemistry PY - 2018/// VL - 14 SP - 560 EP - 575 SN - 1860-5397 DO - 10.3762/bjoc.14.43 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.14.43 KW - aminophenols KW - [4 + 2] cycloaddition KW - dienophile KW - Mannich reaction KW - ortho-quinone methide N2 - This article provides an overview about specifically modified Mannich reactions where the process involves an ortho-quinone methide (o-QM) intermediate. The reactions are classified on the basis of the o-QM source followed by the reactant, e.g., the dienophile partner in cycloaddition reactions (C=C or C=N dienophiles) or by the formation of multicomponent Mannich adducts. Due to the important pharmacological activities of these reactive o-QM intermediates, special attention is paid to the biological activity of these compounds. ER -