TY - JOUR A1 - Demiray, Melodi A1 - Miller, David J. A1 - Allemann, Rudolf K. T1 - Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids JF - Beilstein Journal of Organic Chemistry PY - 2019/// VL - 15 SP - 2184 EP - 2190 SN - 1860-5397 DO - 10.3762/bjoc.15.215 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.15.215 KW - artemisinin KW - amorphadiene synthase KW - oxygenated terpenoids KW - sesquiterpenoids KW - substrate engineering KW - terpenes N2 - 8-Methoxy-γ-humulene, (E)-8-methoxy-β-farnesene, 12-methoxy-β-sesquiphellandrene and 12-methoxyzingiberene can be synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet tightly controlled carbocationic chemistry of this sesquiterpene cyclase. ER -