TY - JOUR A1 - Kaczmarek, Renata A1 - Korczyński, Dariusz A1 - Green, James R. A1 - Dembinski, Roman T1 - Extension of the 5-alkynyluridine side chain via C–C-bond formation in modified organometallic nucleosides using the Nicholas reaction JF - Beilstein Journal of Organic Chemistry PY - 2020/// VL - 16 SP - 1 EP - 8 SN - 1860-5397 DO - 10.3762/bjoc.16.1 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.16.1 KW - alkynes KW - 5-alkynyluridines KW - C–C-bond formation KW - dicobalt hexacarbonyl complexes KW - Nicholas reaction KW - nucleosides KW - propargyl cation N2 - Dicobalt hexacarbonyl nucleoside complexes of propargyl ether or esters of 5-substituted uridines react with diverse C-nucleophiles. Synthetic outcomes confirmed that the Nicholas reaction can be carried out in a nucleoside presence, leading to a divergent synthesis of novel metallo-nucleosides enriched with alkene, arene, arylketo, and heterocyclic functions, in the deoxy and ribo series. ER -