TY - JOUR A1 - Nakashima, Ken-ichi A1 - Tomida, Junko A1 - Tsuboi, Tomoe A1 - Kawamura, Yoshiaki A1 - Inoue, Makoto T1 - Muyocopronones A and B: azaphilones from the endophytic fungus Muyocopron laterale JF - Beilstein Journal of Organic Chemistry PY - 2020/// VL - 16 SP - 2100 EP - 2107 SN - 1860-5397 DO - 10.3762/bjoc.16.177 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.16.177 KW - azaphilones KW - endophytic fungus KW - modified Mosher’s method KW - Muyocopron laterale KW - polyketides N2 - Two new azaphilones, namely muyocopronones A (1) and B (2), were isolated from the cultures of an endophytic fungus Muyocopron laterale ECN279. Their structures were elucidated by extensive spectroscopic analysis. Their absolute configurations were determined using the modified Mosher’s method and through comparisons of experimental and calculated electronic circular dichroism data. In addition, muyocopronone B (2) was found to exhibit a weak antibacterial activity against some Gram-positive bacteria. ER -