TY - JOUR A1 - Lucas, Tobias A1 - Dietz, Jule-Philipp A1 - Opatz, Till T1 - Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt JF - Beilstein Journal of Organic Chemistry PY - 2020/// VL - 16 SP - 445 EP - 450 SN - 1860-5397 DO - 10.3762/bjoc.16.41 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.16.41 KW - cyclization KW - fluorinated heterocycles KW - fluorine KW - pyrazoles KW - pyrimidines N2 - A synthesis of fluorinated pyrimidines under mild conditions from amidine hydrochlorides and the recently described potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency. ER -