TY - JOUR A1 - Liu, Zhenghui A1 - Wang, Peng A1 - Yan, Zhenzhong A1 - Chen, Suqing A1 - Yu, Dongkun A1 - Zhao, Xinhui A1 - Mu, Tiancheng T1 - Rhodium-catalyzed reductive carbonylation of aryl iodides to arylaldehydes with syngas JF - Beilstein Journal of Organic Chemistry PY - 2020/// VL - 16 SP - 645 EP - 656 SN - 1860-5397 DO - 10.3762/bjoc.16.61 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.16.61 KW - cost-effective ligand KW - industrial catalysis KW - reductive carbonylation KW - rhodium catalyst KW - syngas N2 - The reductive carbonylation of aryl iodides to aryl aldehydes possesses broad application prospects. We present an efficient and facile Rh-based catalytic system composed of the commercially available Rh salt RhCl3ยท3H2O, PPh3 as phosphine ligand, and Et3N as the base, for the synthesis of arylaldehydes via the reductive carbonylation of aryl iodides with CO and H2 under relatively mild conditions with a broad substrate range affording the products in good to excellent yields. Systematic investigations were carried out to study the experimental parameters. We explored the optimal ratio of Rh salt and PPh3 ligand, substrate scope, carbonyl source and hydrogen source, and the reaction mechanism. Particularly, a scaled-up experiment indicated that the catalytic method could find valuable applications in industrial productions. The low gas pressure, cheap ligand and low metal dosage could significantly improve the practicability in both chemical researches and industrial applications. ER -