TY - JOUR A1 - Guo, Yafei A1 - Harutyunyan, Syuzanna R. T1 - Copper-catalysed alkylation of heterocyclic acceptors with organometallic reagents JF - Beilstein Journal of Organic Chemistry PY - 2020/// VL - 16 SP - 1006 EP - 1021 SN - 1860-5397 DO - 10.3762/bjoc.16.90 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.16.90 KW - conjugate addition KW - copper catalysis KW - heterocyclic Michael acceptor KW - organometallics N2 - Copper-catalysed asymmetric C–C bond-forming reactions using organometallic reagents have developed into a powerful tool for the synthesis of complex molecules with single or multiple stereogenic centres over the past decades. Among the various acceptors employed in such reactions, those with a heterocyclic core are of particular importance because of the frequent occurrence of heterocyclic scaffolds in the structures of chiral natural products and bioactive molecules. Hence, this review focuses on the progress made over the past 20 years for heterocyclic acceptors. ER -