TY - JOUR A1 - Xiong, Feng A1 - Li, Bo A1 - Yang, Chenrui A1 - Zou, Liang A1 - Ma, Wenbo A1 - Gu, Linghui A1 - Mei, Ruhuai A1 - Ackermann, Lutz T1 - Copper-mediated oxidative C−H/N−H activations with alkynes by removable hydrazides JF - Beilstein Journal of Organic Chemistry PY - 2021/// VL - 17 SP - 1591 EP - 1599 SN - 1860-5397 DO - 10.3762/bjoc.17.113 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.17.113 KW - benzhydrazides KW - copper KW - 3-methyleneisoindolin-1-one KW - removable directing group N2 - The efficient copper-mediated oxidative C–H alkynylation of benzhydrazides was accomplished with terminal alkynes. Thus, a heteroaromatic removable N-2-pyridylhydrazide allowed for domino C–H/N–H functionalization. The approach featured remarkable functional group compatibility and ample substrate scope. Thereby, highly functionalized aromatic and heteroaromatic isoindolin-1-ones were accessed with high efficacy with rate-limiting C–H cleavage. ER -