TY - JOUR A1 - Adusumalli, Krishna M. S. A1 - Konidena, Lakshmi N. S. A1 - Gandham, Hima B. A1 - Kumari, Krishnaiah A1 - Valluru, Krishna R. A1 - Nidasanametla, Satya K. R. A1 - Battula, Venkateswara R. A1 - Namballa, Hari K. T1 - Me3Al-mediated domino nucleophilic addition/intramolecular cyclisation of 2-(2-oxo-2-phenylethyl)benzonitriles with amines; a convenient approach for the synthesis of substituted 1-aminoisoquinolines JF - Beilstein Journal of Organic Chemistry PY - 2021/// VL - 17 SP - 2765 EP - 2772 SN - 1860-5397 DO - 10.3762/bjoc.17.186 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.17.186 KW - 1-aminoisoquinolines KW - CWJ-a-5 KW - intramolecular cyclisation KW - 2-(2-oxo-2-phenylethyl)benzonitriles KW - nucleophilic addition N2 - A simple and efficient protocol for the construction of 1-aminoisoquinolines was achieved by treating 2-(2-oxo-2-phenylethyl)benzonitriles with amines in the presence of Me3Al. The reaction proceeds via a domino nucleophilic addition with subsequent intramolecular cyclisation. This method provides a wide variety of substituted 1-aminoisoquinolines with good functional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated in the successful synthesis of the antitumor agent CWJ-a-5 in gram scale. ER -