TY - JOUR A1 - Malinowski, Zbigniew A1 - Fornal, Emilia A1 - Sumara, Agata A1 - Kontek, Renata A1 - Bukowski, Karol A1 - Pasternak, Beata A1 - Sroczyński, Dariusz A1 - Kusz, Joachim A1 - Małecka, Magdalena A1 - Nowak, Monika T1 - Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity JF - Beilstein Journal of Organic Chemistry PY - 2021/// VL - 17 SP - 558 EP - 568 SN - 1860-5397 DO - 10.3762/bjoc.17.50 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.17.50 KW - amination KW - complexes KW - cytotoxicity KW - Pd cross-coupling KW - phthalazinone N2 - Amino- and polyaminophthalazinones were synthesized by the palladium‐catalyzed amination (alkyl- and arylamines, polyamines) of 4-bromophthalazinones in good yields. The coordinating properties of selected aminophthalazinones towards Cu(II) ions were investigated and the participation of the nitrogen atoms in the complexation of the metal ion was shown. A biological screening of the potential cytotoxicity of selected synthesized compounds on HT-29 and PC-3 cell lines, as well as on the L-929 cell line, proved that some amino derivatives of phthalazinone show interesting anticancer activities. The detailed synthesis, spectroscopic data, and biological assays are reported. ER -