TY - JOUR A1 - Naito, Yuki A1 - Shida, Naoki A1 - Atobe, Mahito T1 - Synthesis of piperidine and pyrrolidine derivatives by electroreductive cyclization of imine with terminal dihaloalkanes in a flow microreactor JF - Beilstein Journal of Organic Chemistry PY - 2022/// VL - 18 SP - 350 EP - 359 SN - 1860-5397 DO - 10.3762/bjoc.18.39 PB - Beilstein-Institut JA - Beilstein J. Org. Chem. UR - https://doi.org/10.3762/bjoc.18.39 KW - electrochemical synthesis KW - electrocyclization KW - flow microreactor KW - heterocyclic amines KW - imine N2 - We have successfully synthesized piperidine and pyrrolidine derivatives by electroreductive cyclization using readily available imine and terminal dihaloalkanes in a flow microreactor. Reduction of the substrate imine on the cathode proceeded efficiently due to the large specific surface area of the microreactor. This method provided target compounds in good yields compared to a conventional batch-type reaction. Furthermore, piperidine and pyrrolidine derivatives could be obtained on preparative scale by continuous electrolysis for approximately 1 hour. ER -